Kidney diseases that can be treated by Stem Cell Transplant in Shijiazhuang
Kidney Disease Hospital:
2. Rapidly Progressive Glomerulonephritis
A scientist used autogenous hemopoietic stem cell transplant treated a mouse
with Crescentic Glomerulonephritis. After transplant, the survival rate of that
mouse increased remarkably; the levels of dsDNA Ab, ssDNA and antoneutrophil
cytoplasmic also decreased. Hematuria, proteinuria and peripheral lymph node
enlargement also alleviated. Deposition of fibrin decreased and formation of
crescent also inhibited. From this experiment we can see how powerful the Stem
Cell Transplant is in treating Glomerulonephritis.
3. Diabetic Nephropathy
Kidney damage is a common complication of Diabetes. Diabetes leads renal
microcirculation obstructed resulting in oxygen and blood insufficiency of the
kidney, damage of renal intrinsic cells and proteinuria. Loss of massive
proteins leads to Hypoalbuminemia which decreases oncotic pressure of plasma and
causing edema. Damaged renal intrinsic cells fail to regulate fluid and
electrolytes normally causing water and sodium retention and as a consequence,
edema appears. In this case, treating of Diabetic Nephropathy should focus on
repairing damaged renal intrinsic cells and preventing further deterioration of
the kidney. Diabetic Nephropathy happens in relation to many factors such as
Hyperglycemia, abnormal hemodynamics of the kidneys as well as familial
heredity.
Either primary or secondary causes cause blood glucose elevating which change
renal hemodynamics. Then, elevated glomerular perfusion and filtration increases
the pressure to the glomerular capillaries hurting renal intrinsic cells. That
broadening of mesangium; fusion of epithelial cell foot processes and formation
of dense droplets detaching glomerular epithelial cells from glomeruli therefore
thickens glomerular basement membrane and eventually, diffuse mesangium, nodular
lesions activate the process of Kidney Fibrosis leading to glomerular sclerosis.
According to this, preventing or delaying development of Diabetic Nephropathy is
very important to reduce the morbidity rate of Diabetes. Stem Cell Transplant
can increase the actual number of functional renal intrinsic cells thus
improving kidney function and making the patients lives normally. (To be
continued)