Stem Cell Therapy is no longer a new technique for people all over the world.
Treating kidney diseases by Stem Cell Therapy have been practiced clinically.
Stem cells are known as Universal cells because they have the superpower to
differentiate into various cells of tissues and organs of the human body. Stem
cells are a group of undifferentiated cells that can be cultured in vitro and
then be directed to differentiate certain cells. Stem cell therapy provides a
new and promised treatment for patients with kidney diseases.
In China, with the support of government development of Stem cells in
treating kidney disease improves day by day. In 2010, the first Stem Cell Centre
for kidney disease was founded in Shijiazhuang, the capital city of Hebei
Province, China. This Stem Cell Centre is authorized to do studies of stem cells
in the nephrology field and practice clinically. This centre belongs to
Shijiazhuang Kidney Disease Hospital. So, what are those kidney diseases can be
treated by Stem Cell Transplant in Shijiazhuang Kidney Disease Hospital?
In Shijiazhuang Kidney Disease Hospital, cord blood stem cells are the most
common stem cells that applied clinically. Besides, cord blood stem cells have
close relationship with kidney disease. Cord blood stem cells are easy to be
separated; their proliferation ability is very considerable; and they have very
low immunogenicity that rejection almost will not happen. In Shijiazhuang Kidney
Disease, Stem Cell Transplant is applied to treat the following kidney
diseases:
The principle of treating IgA Nephropathy by stem cell transplant is that,
variant stem cells can inhibit the production of autoactive T cells which
decrease the production of IgA antibodies.
1. IgA Nephropathy
Pathogenesis of IgA Nephropathy is not yet figured out at present. There are
some experiments shows disturbing immune system plays an important role in the
development of IgA Nephropathy. Many medical scholars believe that IgA
antibodies are not antigen-dependent. They think IgA Nephropathy is a kind of
stem cell disease. For patients with IgA Nephropathy, abnormal increased levels
of autoactive T cells are found. Peripheral blood increase excessive IgA
antibodies are also detected. Professor Sakai used variant bone marrow stem
cells treating a patient with both leukemia and IgA Nephropathy. After variant
bone marrow stem cells transplant, leukemia was treated and deposition of IgA
immune complex in mesangial area of kidney also disappeared. The principle of
treating IgA Nephropathy by stem cell transplant is that, variant stem cells can
inhibit the production of autoactive T cells which decrease the production of
IgA antibodies. (To be continued)