Many kinds of diseases will make the renal tissues get diseased and bring
Nephrotic Syndrome to people. The pathology of this disease is very complicated
and it belongs to a common autoimmune disease. Now let’s get to know something
about Nephrotic Syndrome.
Nephrotic Syndrome is group of clinical syndrome with many causes including
Chronic Nephritis. Its main clinical manifestations are massive proteinuria,
severe edema, Hypoproteinemia and Hyperlipidemia.
The pathological mechanism of Nephrotic Syndrome:
The function of glomerular filtration membrane is damaged and more protein
leaks out and forms proteinuria; massive protein is lost by urine and serum
protein decreases, which can change the balance of liquid exchange between
capillaries and tissues; then, water and sodium deposit at tissue space and
cause edema. The decrease of effective blood volume makes the excretion of
renin, angiotensin and aldosterone increase, thus leading to the retention of
water and sodium. In addition, the decline of glomerular filtration rate due to
decreased renal blood volume can also promote the occurrence of edema.
The clinical manifestations of Nephrotic Syndrome:
The main clinical manifestations are massive and enduring proteinuria, edema,
Hyperlipidemia, etc. If patients’ blood volume is insufficient, hematuria and
urea nitrogen always rise slightly, which is caused by that glomerular
filtration rate decreases while glomerular reabsorption keeps normal. Renal
Syndrome commonly occurs in children, and the symptoms are not obvious in the
early stage and in the late phase, the symptoms are reflected as: hydrops in
eyelid and visceral serous cavity, such as pleural effusion and ascites;
patients with severe edema, their skin will become thin and transparent and may
seep liquid if there is wound. The edema will affect blood circulation and
worsen local immunity, which can easily cause infections.
Experts say that although primary kidney diseases and secondary ones have
similar clinical manifestations of Nephrotic Syndrome, the pathogenesis and
relevant treatments are rather different. So the identification on them is
necessary and important
The above is a brief introduction about Nephrotic Syndrome. We hope that
people can gain more knowing about this disease and take effective prevention
measures.