Clinically, IgA Nephropathy is characterized by hematuria; pathologically, it
is featured by the sedimentation of IgA or IgA particles at glomerular mesangial
region. It is a type of primary Glomerulonephritis. In the development of IgA
Nephropathy, hematuria and proteinuria may appear together with high blood
pressure caused by renal impairments. Approximately 1% to 2% of the diagnosed
IgA Nephropathy patients will arrive at terminal renal failure that is called
Uremia clinically.
With the deepening of research and experiment, medicines for treating IgA
Nephropathy have aroused more attention from both doctors and patients. At
present, in clinical treatments, the following medicines are commonly used.
1. New Nephritis Capsule
It can inhibit the proliferation of mesangial cells and control the
inflammatory reactions within a short period of time.
2. TWP caplet
It is mainly used for IgA Nephropathy patients with hematuria and
proteinuria. And patients can stop taking it when proteinuria turns negative and
meanwhile continue using Chinese medicine to protect and repair damaged renal
tissues, thus avoiding relapse when some inducing factors occur after
proteinuria authentically become negative. .
3. Hormones: Prednisone and Methylprednisolone
Clinically, they have distinct therapeutic effects for those IgA Nephropathy
patients who suffer from massive complications and sharply-worsened renal
functions.
4. Immunosuppressive Agents
After a number of clinical observations, experts have found out that the
combined application of various immunosuppressive agents together with
Micro-Chinese Medicine Osmotherapy have a favorable therapeutic effect for those
patients who depend on and resist against hormones. The immunosuppressive agents
can temporarily control the clinical complications and relevant inflammatory
reactions within a short period of time. And the Micro-Chinese Medicine can
repair the damaged renal tissues and rebuild renal functions. The
immunosuppressive agents mainly include cyclophosphamide, mycophenolate mofetil
(i.e. cellcept), cyclosporine, azathioprine, etc.
5. Angiotensin-Converting Enzyme Inhibitors and Antiotensin Receptor
Antagonists
They have inhibiting effects on angiotensins which can ease the high blood
pressure caused by the damage of kidney and control the blood pressure in a
certain range within a short period of time.
6. Medicines of Anticoagulation and Anti-Platelet Aggregation
They can prevent the abnormal clotting in glomerulus and ease the aggregation
of platelet and the formation of thrombus. These medicines include dipyridamole,
warfarin, low-molecular heparin and urokinase.
7. Fish Oil
Research has proven that the IgA Nephropathy patients lack some essential
fatty acids like unsaturated fatty acid ω-3 which can not be composed by human’s
body. Fish oil contains abundant ω-3 which can promote membrane fluidity and
reduce platelet aggregation. So fish oil can reduce proteinuria to a certain
degree.
8. Micro-Chinese Medicine Osmotherapy
After many years of research and experiment, Shijiazhuang Kidney Disease
Hospital concludes an innovative therapy which is called Micro-Chinese Medicine
Osmotherapy to deal with various kidney diseases including IgA Nephropathy. The
therapeutic mechanism of this therapy is to block renal fibrosis, repair damaged
renal intrinsic cells and rebuild the normal structure, and the realizing of
these purposes is based on Chinese medicine curative effects like dilating blood
vessels, anti-inflammation, anticoagulation, preventing blood viscosity and
degrading extracellular matrixes.
9. Stem Cells Transplant
Stem Cells Transplant is the most advanced therapy for treating kidney
disease. Stem cells are implanted into the body through intravenous injection,
and with the function of homing, stem cells can target the renal lesions and
differentiate into various functional cells which can replace the damaged renal
cells and tissues. Thus, Stem Cells Transplant can bring new hope to IgA
Nephropathy patients.
According to the different illness conditions of patients, these medicines
can be used alone or jointly, but they can not solve the root cause of
proteinuria and hematuria. When the disease develops into a certain degree, high
blood pressure will appear which can hardly be controlled by
angiotensin-converting enzyme inhibitors and antiotensin receptor antagonists.
That’s why many patients can not reduce the high blood pressure by long-term
taking antihypertensive medicines.
There will be quick therapeutic effects for treating IgA Nephropathy by
either hormones or immunosuppressive agents, but the effects are temporary.
Shijiazhuang Kidney Disease Hospital take combined therapy of Chinese and
Western medicines: Western medicine is used for easing complications and
Micro-Chinese Medicine is used for repairing renal tissues and restoring renal
functions, which can bring favorable effects to patients.