Clinically, ESRD is a kind of common kidney disease whose harmfulness is
tremendous. There are many factors which can lead to the occurrence of ESRD, so
patients should pay much attention to them and effectively prevent it.
In general, for ESRD patients, their autoimmunity decreases or the mechanism
of organic immunoregulation shows abnormality. Under this circumstance, if
patients also suffer from colds, infections or excessive fatigue, the virus will
easily ruin the defense barrier of the body and pose direct damage to the
kidney. From the viewpoint of medical science, such kind of kidney damaged by
virus has undergone fibrosis degeneration. The fibroid part of kidney will fail
to perform its intrinsic function, which means that some substances which should
be excreted out stay in the body and some others which should be stored in the
body while leak out. As a result, protein and red blood cells in the bodies of
Uremia patients leak out from the diseased kidney, which will finally lead to
proteinuria, hematuria. On the other hand, creatinine, urea nitrogen, uric acid,
white blood cells and water are left in the body while, which can result in the
increase of creatinine and urea nitrogen and the appearance of inflammation and
edema.
In fact, the above symptoms just belong to the early stage of kidney disease.
If patients don’t take effective measures to ease the conditions of fibroid
renal tissues, the remaining healthy parts will also gradually experience
fibrosis. The damaging process of kidney is just like that a dam has a small
hole, but people do not mend it and the hole will get bigger and finally ruin
the whole dam.
Without any treating measures, the fibroid part of kidney will develop
gradually from 10% of the total to 30%, 50% and even more. Beyond that, with the
development of fibrosis, the process will get accelerated, because more fibroid
renal tissues lead to decreasing nephrons and bring heavier workload to the
remaining healthy part of kidney. Overwork will shorten the lifespan of kidney
sharply and if the renal fibrosis reaches 90% of the total, Uremia will come
into being.
A detailed knowing of the causes of ESRD can help patients take some
preventing measures to avoid it and attach enough attention to some minor
changes.
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