The sedimentation of IgA-based antibodies and immune complexes at glomerular
mesangial area can lead to the damage of mesangial cells, which will cause a
series of inflammatory reactions. These inflammatory reactions are called IgA
Nephropathy. Although IgA Nephropathy can be well treated by hormone, the
disease will reoccur very easily. So patients would better choose Stem Cell
Transplant instead of hormone therapy. Then, how about the therapeutic effect of
Stem Cell Transplant in treating IgA Nephropathy?
IgA Nephropathy is a kind of Chronic Glomerular Disease which has many
pathogenesis and the same immune pathological features. Clinically, there are
40% to 50% of patients have gross hematuria or microscopic hematuria while 35%
to 40% of patients can appear microscopic hematuria accompanied by proteinuria,
and others show Nephrotic Syndrome and Kidney Failure.
Stem Cell Transplant has achieved good effects in treating kidney diseases.
Stem Cell Therapy can treat IgA Nephropathy fundamentally. It will affect the
kidney lesions directly, and then improve the condition of hypoxia-ischemia,
reduce the continuous damage of all kinds of cells in kidney, and finally
restore the function of damaged cells caused by hypoxia-ischemia.
At present, Stem Cell Therapy is the most advanced treatment for IgA
Nephropathy in the world, which infuses stem cells to patients’ bodies through
blood circulation. Stem cells have the ability of automatic homing which can
reach kidney lesion directly, and then repair renal function. This method has
achieved a significant therapeutic effect on IgA Nephropathy and many other
refractory diseases.
After stem cells are transplanted into human body, they will infinitely
proliferate and then differentiate into immunocytes. Therefore, stem cells can
rebuild immune functions and facilitate human body to produce some well
functioning antibodies which will play the immune function. At this moment,
those internal pathogenic antibodies will be suppressed, thus achieving the goal
of regulating immunity. At the same time, stem cells will repair renal cells
continuously and glomerular basilar membrane can also be restored. Thereby, the
symptoms such as proteinuria and blood occult will disappear gradually. Those
damaged renal cells can be restored and functions can be rebuilt, realizing the
goal of treating disease eventually. IgA Nephropathy will rarely relapse by
using Stem Cell Transplantation, which can achieve the purpose of treating
symptoms and diseases.
At present, according to the investigation, there is no reoccurrence case
after the application of Stem Cell Transplant. This has greatly improved the IgA
Nephropathy patients’ quality of life.