Most people know little about IgA Nephropathy, let alone its pathogenesis.
Many people may ask with curiosity that what iga is and what IgA Nephropathy is.
Actually, although the name of this disease is weird with obvious clinical
manifestations, it is just like a paper tiger which is outwardly strong but
inwardly weak. Gross hematuria is a distinct symptom of this disease, but it
always has a favorable prognosis and will not develop into Uremia.
In fact, only 15%-20% of the patients should take active treatments, because
they may suffer from Renal Failure 10 years later. Therefore, IgA Nephropathy is
more a combination of two diseases than a kind of kidney disease. A correct
beforehand judging is very important for the treatment of InA Nephropathy. There
are some judgment standards for those diseases which may develop into Chronic
Kidney Failure, such as persistent proteinuria, sustaining high blood
pressure.
The common symptoms of IgA Nephropathy include hematuria, proteinuria, high
blood pressure, lumbago, headache, etc. However, massive proteinuria and high
blood pressure indicate renal damages of different degrees with unfavorable
prognosis. At this time, the IgA Nephropath patients with these symptoms should
be alert. In dealing with the complications, patients should take active
measures to treat the disease from the root cause which means repairing damaged
renal tissues and rebuilding renal functions.
1. Fully know the state of renal functions.
Objectively detect the glomerular filtration rate and estimate the tubular
functions. If IgA Nephropathy appears recently, patients should consider not
only the common reversible factors but also Nephritis.
2. Find the pathogeny through renal biopsy.
For those IgA Nephropathy patients with rapidly-aggravating
Glomerulonephritis, they should take repeated renal biopsy to get to know
whether there is newly-appearing crecentic glomerulonephritis, which can also
differentiate between crecentic glomerulonephritis and acute tubular necrosis.
If massive cellular crescents appear , except for applying Micro-Chinese
Medicine Osmotherapy to protect the kidney, patients should also use hormone and
immunosuppressive agents (mainly refer to cytoxan) to cope with the
complications, thus treating IgA Nephropathy by combined Chinese and Western
medicines.
3. Early treatments.
In the early stage, IgA Nephropathy patients should strengthen the treatment
for the primary diseases, and if those primary diseases can be well controlled,
renal functions can get different degrees of recovery. When controlling diet and
regulating blood pressure, patients should also insist on taking Micro-Chinese
Medicine Osmotherapy, which can greatly delay the aggravation of renal
functions.
4. Characteristic therapy for IgA Nephropathy.
In treating IgA Nephropathy, the optimal therapeutic effects can be achieved
through strict procedures and effective measures. The therapeutic mechanism of
treating IgA Nephropathy by Micro-Chinese Medicine Osmotherapy is as
follows:
a. Dilating blood vessels. The stimulus of IgA immune complexes result in
ischemia-hypoxia of kidney. Dilating blood vessels is aimed at improving renal
micro-circulation and easing renal ischemia and hypoxia, thus providing a
favorable environment for repairing mesangial cells.
b. Anticoagulation. The increase of inflammatory cells in blood will send up
the viscosity of blood, which can promote the formation of micro-thrombus in
glomerular capillaries. Micro-Chinese Medicine can block the formation of blood
thrombus and keep blood flow unobstructed.
c. Anti-inflammation. It is aimed at reducing the infiltration of
inflammatory cells and ease the further damages of glomerular mesangial
cells.
d. Degradation. Micro-Chinese Medicine can degrade the sedimentation of IgA
immune complexes in mesangial region and the extracellular matrixes. This
process can protect glomeruli from sclerosis.
The above procedures can block the sclerosis of kidney, repair damaged
intrinsic cells and rebuild renal structure.