Clinically, Diabetic Nephropathy can be divided into five stages, and
patients have different symptoms in these five stages. Now this article will
give some detailed introductions about them.
★Stage 1
This stage featured by large renal volume which enlarge by 25%, this can be
seen by B ultrasound. The glomerular filtration rate (GFR) rises, exceeding
120ml/min and even reaching 150ml/min which is equal to that of blood sugar.
Renal biopsy shows no abnormality and blood pressure keeps normal. Due to that
it is the early stage of Diabetes, these symptoms can recover to a normal level
under the circumstances of strict controlling blood sugar and receiving insulin
therapy for several weeks to several months.
★ Stage 2
In this stage, the excretion of albiduria protein shows no increase when the
patient is at rest, but after exercise, the excretion will increase. For
example, if the patient rides a bicycle, which makes his heart rate reach 75% of
the highest heart rate of his peers, for 20 minutes, the one-hour excretion of
albiduria protein can exceed 20 MCG/min and the glomerular filtration rate can
recover to the normal level. If the filtration rate keeps high, that means
patients are in the period of high risk of Diabetic Nephropathy, and the illness
condition can be reserved.
★ Stage 3
In terms of early Diabetic Nephropathy, the continuous urinary protein
transformed from post-exercise albiduria protein increases up to 20---200
MCG/min and the glomerular filtration rate maintain normal. In the late stage,
the blood pressure may slightly increase and if patients do not take some
effective treatment measures, 90% of them will suffer from serious Diabetic
Nephropathy.
★ Stage 4
It is the stage of distinct Diabetic Nephropathy (or the stage of clinical
Diabetic Nephropathy). In this stage, continuous urine protein occurs and the
ration of urinary protein exceeds 0.5g/24h which equals that the excretion rate
of albiduria protein exceeds 200MCG/min. And the glomerular filtration rate
decreses accompanied with Hypertension. If the blood pressure can not get under
good control, the glemerular filtration rate will decrease at an average speed
of 1---1.22ml per month and deteriorate constantly, and patients will suffer
from late Renal Failure within 5 to 8 years.
★Stage 5
It is the late stage of Diabetic Nephropathy. In this stage, the blood
pressure goes up dramatically, urine protein decreases and the glomerular
filtration rate can drop below 10ml/min. At the same time, Urea nitrogen and
creatinine rise, Edema and Hypertension further aggravate and Hypoproteinemia
occurs. Diabetic Rtinopathy and Diabetic Neuropathy always presented in this
stage too. To learn more information, please Email us at khkpcn@hotmail.com