1.Genetics
People have known that the occurrence of Diabetic Nephropathy is related to
genetics for ages. The occurrence rate and degree of severity are different for
different racial DN patients, and that means the same family has high morbidity,
and some families suffer most even in the same ethnic group. Clinically, we
usually find that DN still occurs in some diabetic sufferers with reasonably
controlled blood sugar meanwhile some diabetic sufferers with unreasonably
controlled blood sugar do not suffer from DN at all. That partly illustrate that
the occurrence of Diabetic Nephropathy is highly related with genetics.
2.Hyperglycemia(high blood sugar)
A 1985 report from the WHO DN research group revealed that DN is common in
people whose fasting blood glucose is >7.8mmol/L. High glucose, which is the
feature of Diabetes, leading to a series of metabolic disturbance is the main
cause of Uremia. After long-term increased blood glucose, renal tissue proteins
react with molecules of glucose, which leading to altered biochemical structure
of the protein and eventually the occurrence of proteinuria. Strict control over
blood glucose on Type 1 and Type 2 Diabetic sufferers can delay the occurrence
of micro-albuminuria and curb the process of leading to clinical
proteinuria.
3. Hypertension (high blood pressure)
High blood pressure which accelerates the development of DN and undermines
renal function is also a main cause of DN, even causes uremia. Most high blood
pressure is secondary to Type 1 Diabetes, but for Type 2 Diabetes, high blood
pressure occurs before Diabetes.
However, there is one thing in common that hypertension make Diabetes
deteriorate, so carefully control over blood pressure is necessary, especially
for sufferers afflicted by Type 1 Diabetes, if effective measures of controlling
blood pressure have been taken in the early stage of DN, the occurrence of
uremia can be delayed for 10 to 20 years.