Principle and Therapeutic Effects of Treating Diabetic Nephropathy by Stem Cells Transplant

Principles:
Mesenchymal stem cells have not only common characteristics of most stem cells, including self-renewal and multilineage differentiation and the ability of homing, but also its special advantages - low immunogenicity. Therefore, they were used as an ideal seed cells for repairing impaired tissues and organs caused by damage repair. According to research about diabetes treatment by using stem cells in recent years, many laboratories both home and abroad reported researches about mesenchymal stem cells (MSC) transplantation in treating Diabetics. It turned out MSC transplant works for both Type 1 and Type 2 diabetes. Transplanted MSC are mostly derived from bone marrow. They can be used in direct transplant or indirect transplant in differentiating into insulin-secreting cells first. Both methods can lower blood sugar remarkably. In addition, it found that mesenchymal stem cells can differentiate into renal parenchymal cells,such as mesangial cells, podocytes, tubular epithelial cells as well, which make another basis for treating diabetes.
Therapeutic Effects
First, mesenchymal stem cells can repair impaired renal intrinsic cells
Second, mesenchymal stem cells can differentiate into renal intrinsic cells
1. Differentiate into epithelial cells, and accelerate the regeneration of tubular epithelial cells, because MSC may have some growth and nutritional factors which can accelerate the production of renal tubular epithelial cells and has functions of anti-mitotic apoptosis, promoting proliferation and etc.
2. Differentiate into glomerular mesangial cells, podocytes and interstitial cells.
Recent research has shown major breakthroughs are possible when it comes to treating and curing diabetes with stem cells. Type 1 Diabetes is particularly difficult to cure, as the body has attacked and destroyed insulin-producing cells. Before the future can become real, numerous safety issues regarding human stem cells need to be addressed, and a renewable source of human stem cells must be created. For more information, please Email us at khkpcn@hotmail.com