Renal Failure can be the result of many reasons like Hypertension, Diabetes,
genetic diseases like Polycystic Kidney Disease (PKD), immunological related
disease like IgA Nephropathy, or direct kidney injury by renal toxic drugs and
so on. Kidney is an organ where blood filtration takes places. And the
pathological changes of kidney are almost all related to blood circulation
within and outside of the kidneys.
In order to make explain how these above mentioned factors affect kidneys and
lead to final kidney function decline, we need first to make clear the most
important tissue of kidneys----glomerulus.
Glomerulus consists of massive blood capillaries, and is the main place where
blood filtration takes place. Once there is blood capillary break, squeeze, or
block, pathological changes of blood vessel cells can easily take place and lead
to overall kidney function decline. And, the above mentioned several factors
damages kidneys mainly through affecting blood circulation within the
kidneys.
Hypertension can easily lead to blood hyper transfusion into kidneys.
Hypertension within kidneys not only lead to blood capillary break down, but
also damages of filtrating barriers (endothelial cells, basement membrane and
the epithelial cells). The damage of glomerular filtrating barriers gives rise
to further damages of other renal tissues like renal tubules and intestinal
cells, which accelerates the aggravation of kidney failure.
Diabetes damage kidneys through direct injuring kidney blood capillaries. It
is known well that the most common complication of Diabetes is arteriosclerosis
caused by dysfunction of glucose metabolism. Arteriosclerosis with in kidney
capillaries can easily give rise to blood circulation blocks and following
insufficient blood supply to kidney cells. Cellular necrosis and kidney function
decline will be the final result.
Immunological related kidney diseases like Lupus Nephropathy or IgA
Nephropathy are closely related to the immune complexes deposition in kidneys,
which leads to pathological changes of the kidneys. Pathological change of
kidneys gradually gives rise to final kidney function decline. This is kind of
similar to renal toxic drug influence to kidneys.
Another common causation of Renal Failure is Polycystic Kidney Disease (PKD).
With the swelling up of these cysts, more and more pressure will be added to
kidney functional tissues like glomerular blood capillaries and renal tubules.
Finally, kidney function decline will finally be the result.
In summary, hypertension, diabetes, PKD and renal toxic drugs can all be the
causation of kidney function decline. Based on different causation there are
corresponding treatment methods. For more information, you can contact me at
khkpcn@hotmail.com.