When we talk of serum Creatinine, we mean Endogenous Serum Creatinine which is the metabolin of muscle. Through irreversible non-enzyme dehydration response, creatine can gradually become creatinine in muscle which is discharged into blood and then discharged out of body along urine. Serum Creatinine is micro-molecular substance which can be filtrated out by glomerulus with less reabsorbed by nephridial tubules. The creatinine formed in human body is almost discharged out of body along with urine and usually is not affected by urine volume. Clinically, serum creatinine is the key indicator for kidney function.
Usually speaking, the expected range of serum creatinine is 44-133umol/L. when serum creatinine in over 133umol/L, it means that the kidney is damaged and it can be Renal Insufficiency or renal Failure. When serum creatinine is above 133umol/L, it is the inflammatory damage stage; when over 186umol/L, it is the stage of renal damage; when over 451umol, it is the stage of renal failure (uremia at the end stage).
High serum creatinine usually means that kidneys are damaged. Though serum creatinine can reflect the situation of renal parenchyma, it is not a sensitive indicator, for serum creatinine will rise apparently only when the GFR declines to 1/3 of normal one. It means that patients don’t feel anything wrong when the renal damage is mild. If people have the symptoms like nausea, vomit, and dizziness, the renal damage is serious at the moment when serum creatinine begins to rise apparently. Therefore, people have to take a regular examination for kidneys. Early detection and timely treatment will prevent it from developing into Renal Failure or Uremia.
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