Common Sense of Serum Creatinine

People should see a doctor for an overall examination if there is something wrong with their kidneys, and the test report may show your serum creatinine is high, and then doctor may say there must be some problems in your kidneys. We feel doubtful about a series of indexes on the laboratory sheet, so what is the normal range of serum creatinine?

I What is serum creatinine?
The word "serum creatinine" is difficult to understand for many patients. In fact, serum creatinine is the break-down products of muscle metabolizing. Creatinine is formed slowly in human muscles by creatine’s irreversible nonenzymic dehydration reaction. It will be released into blood and finally discharged outside the body though urine. The kidneys own the functions of filtration and excretion, so there is a closed relationship between kidneys and creatinine. For healthy people, the creatinine will be discharged from the urine instead of being absorbed by kidney tubules. Clinically, serum creatinine test is one of the main methods that is commonly used to diagnose kidney function.

II What's the normal range of serum creatinine?
The reference value of serum creatinine varies from different regions and different hospitals. Generally speaking, the range of reference value of serum creatinine is between 44-133 umol/L, which means that kidneys have been damaged when the value of serum creatinine is higher than 133 umol/L.

III Why serum creatinine increases?
Due to the closed relationship between serum creatinine and kidneys, so the value of serum creatinine reflects damaged situation of renal parenchyma exactly. In most situations, different serum creatinine value means that your kidneys are damaged in different degrees. We should understand that the metabolic capacities of human kidneys are strong. We won’t feel discomfort obviously when the kidneys are damaged slightly. The kidneys have already been damaged seriously once we feel physical abnormalities, such as vomiting, puked or dizzy. Therefore, the serum creatinine will still be normal in the early-stage kidney disease or kidneys are damaged slightly. There will be an obvious increase of serum creatinine concentration when the filtration function drops to the one-third of healthy person. So we say that increase of serum creatinine means serious damage of kidneys.
Patients want to lower their creatinine level but the more important thing they should care about is their kidney function, we hope everyone can know that creatinine will not be high if there is no damage on kidney, so repair damaged kidneys is primary thing for them. If we do not want to disease relapses, treating kidneys fundamentally.

The Relationship Between Serum Creatinine and Kidney Function

When we go to the hospital and be told that there is something wrong with kidneys, the main indicators to prove damage on kidneys are Urea Nitrogen and SERUM CREATININE, the latter is often be used to be the indicator of kidney function. So it is necessary for us to understand the relationship between serum creatinine and renal function.

The word "serum creatinine" is difficult to understand for many patients with kidney problem, because they do not have much knowledge about nephrology. Let's put it simple, serum creatinine is the break-down products of muscle metabolizing. Creatinine is formed slowly in human muscles by creatine’s irreversible nonenzymic dehydration reaction, and after processing (filtration and excretion) by kidneys, it will be released into blood and finally discharged outside the body though urine. So there is a closed relationship between kidneys and creatinine. In case that daily-produced serum creatinine can not be discharged though urine, then the concentration of serum creatinine will increase, the higher the creatinine is, the worse the renal function will be. However, for some kidney disease patients, although their kidney function is OK, it does not means that there is no problem about kidney function.
There are two kidneys in human body, normally, however, one kidney is enough to meet the physical requirement. That is because kidneys have a strong compensatory capacity. Therefore, some renal failure patients could receive donation of kidney and continue to their life. General speaking, the level of creatinine will rise only when the renal function is already lower than 50% ~ 30%. In other words, if someone found that his/her serum creatinine rises, it means that his/her renal function is already lose more than 50%.

Serum creatinine also has relationship with human's muscle, weight and age, same level of serum creatinine means different for different people. For example, same level of creatinine means OK for Arnold Schwarzenegger (former World Bodybuilding Champion) but means serious problem on kidney for thin, bedridden old man. On the other hand, Serum creatinine may also raise when someone eats a lot of meats, and for the women in middle and end-stage of pregnancy, their serum creatinine will lower. So clinically, creatinine can be converted to Creatinine Clearance Rate to achieve the goal of precise judgment of renal function.

What is the Meaning of High Serum Creatinine and High Urea Nitrogen

When I communicate with kidney disease patients, their first question usually is: what does the high creatinine mean? Does it suggest my kidney have been damaged? 

The normal level of serum creatinine is less than 133.3umol/L (1.5mg/dl). In the normal condition, the production speed of creatinine in the body and the glomerular filtration speed are in balace. And when the glomerular filtration function declines, the serum creatinine will rise. But because our body has strong compensation and the serum creatinine won't rise obviously until the glomerular filtration rate decline to 1/3 of the normal level. So in the early stage of renal dysfunction, although the creatinine clearance rate drops, usually, the serum creatinine is normal. And just in the decompensation of renal insufficiency, the serum creatinine will rise apparently. But we can find the pathological change by the ECT. The low creatinine can be seen during normal pregnancy. It also can be presented in patients with muscular dystrophy diseases.

The clinical meaning of the urea nitrogen change:
Urea nitrogen is the end product of human protein metabolism. Liver is the main organ producing urea nitrogen and kidney is the main organ discharging it. The urea nitrogen production depends on the intake of protein from the diet, protein catabolism, and liver function. Usually, all of the urea nitrogen in the blood can be filtrated by the glomerulis and a small part will be reabsorbed by the renal tubules. So the amount of urea nitrogen in the blood also can judge our renal function, but not quite sensitive, because it will not rise until the renal function declines to 1/2 of the normal level which is 2.5-7.6mmol/L (7-20mg/dl).

The level of urea nitrogen is easily be affected by the diet, renal blood flow and protein decomposition. In general, the ratio of blood urea nitrogen to the serum creatinine is 10. The rising ratio suggests that most azotemia is caused by the prerenal factors, like gastrointestinal bleeding, cardiac insufficiency; the decreased ratio may suggest the pathological change of renal parenchyma itself, or the excessively insufficient intake of protein and serious hepatic insufficiency etc.

I hope the above information can help you to have a general understanding of your own illness condition. If you want to know more about kidney disease, you can consult our experts online. Wish you a good health!

What is the Serum Creatinine Level that Requires Dialysis for Patients with Kidney Disease

High serum creatinine is the typical symptom of kidney disease patients. What's more, high serum creatinine can do harm to human body including the kidneys in return. Recently, some patients asked me what is the serum creatinine levels that requires dialysis. I think this is the question in the mind of many patients with kidney disease.

In fact, there is no need to do dialysis as soon as the serum creatinine just begins to increase. Then what is the serum creatinine level that requires dialysis? It varies from one country to another. In western countries, when the patient’s creatinine is more than 450 umol/L, his or her doctor will suggest them to do dialysis. Sometimes it depends on the illness condition. When some patients have the symptoms of nausea, vomit, weakness and lassitude, they are also suggested to do dialysis.

Dialysis can be helpful for people with serious kidney disease. The core function of dialysis is to lower the serum creatinine level, to clear up the extra toxins and excess water in blood, and adjust the electrolyte disorder. In one word, it is used to replace the original renal function. That's why we call dialysis artificial kidney. In the case of serious kidney disease, dialysis work effectively and quickly and can make patients survive life-threatening disease.

But once patients begin to be on dialysis, they will live on it and can not be free of dialysis, for dialysis can not treat the kidney disease at all. It just lowers the serum creatinine and almost does nothing to the damaged renal cells which is the cause of high serum creatinine. As the illness condition becomes more serious, the number of nephrons will decrease. As a result, it is difficult to treat the kidney disease. At the same time, it will impose a heavy economic burden on patients.

Long time dialysis will lead to a series of complications like cardiovascular disease, infection and anemia etc., which also make the treatment more difficult.

As the main cause of high serum creatinine is the damaged renal cells, we have to restore the damaged renal cells if we want to reduce the serum creatinine effectively.

Immunotherapy is brand new method to treat kidney disease by regulating the overall immune system. If it can be used with Micro-Chinese Medicine Osmotherapy, the treatment effect will be good. For more information about serum creatinine and how to reduce it effectively, please feel free to contact us online or email us at khkpcn@hotmail.com. We do our best to help you, if we can. Best wishes!

The Effective Way to Treat High Creatinine Levels

There is some relation between creatinine levels and muscle. That is creatinine is the metabolin in muscle. About 20 g muscle can produce 1 mg creatinine. As the glomerulus work to filtrate out the creatinine and discharge it out of body, high creatinine levels indicate that there is something wrong with the kidneys. Creatinine includes two types: exogenous creatinine and endogenous creatinine. Exogenous creatine is the result of meat metabolism in body; endogenous creatinine is the metabolin of muscle tissues of human body. And creatinine can be classified into serum creatinine and urine creatinine. Urine creatinine refers to the creatinine which is filtrated out by glomerulus and discharged out of body along urine. The serum creatinine level of healthy people is 88.4—176.8uml/L and the expected range of urine creatinine is 8.4-13.25mmol/24 h.

In western country, western medicine is adopted to treat high creatinine levels. The most commonly used western medicine is hormonal drugs. The creatinine level can be obviously lowered when western medicine is used. But the shortcoming of this method is that the creatinine levels will relapse when no medicine is used. As a result, kidney disease reoccurs again and again and it makes the renal damage more serious. Finally, it can lead to renal failure, which impose threat on patient’s life.

In contrast, Micro-Chinese Medicine Osmotherapy and Immunotherapy is more effective in lowering creatinine levels while treating uremia, renal insufficiency. Micro-Chinese Medicine Osmotherapy can restore the damaged renal cells. The active ingredients can directly work on the renal lesions of glomerular basal lamina to restore it. After the basal lamina is restored, the filtration area increases and the serum creatinine will naturally decrease. In daily life, one has to have a special diet, be in a good mood, avoid being tired, and control the blood sugar and blood pressure. At the same time, the curative effect will be better if Immunotherapy is adopted. 

The combination of Micro-Chinese Medicine Osmotherapy and Immunotherapy makes the prognosis of kidney disease when treating high creatinine levels. If you want to know more information about Micro-Chinese Medicine Osmotherapy and Immunotherapy, please feel free to contact us on line or email us at khkpcn@hotmail.com.

How to Cure Increased Serum Creatinine of Patients with Renal Failure

For those patients suffering from renal failure, the increase of Serum Creatinine (Scr) marks the further deterioration of renal impairment and the poor control of renal fibrosis, which will eventually develop into Uremia, the later period of renal failure. About the treatments of increased Scr of the patients with renal failure, we give the following introductions:

In Western medicine, the most common treatments are drug and dialysis. Drug can only reduce creatinine simply. Some patients only emphasize the simple reduction of creatinine, while ignoring the protection of kidney, so as to accelerate the process of renal fibrosis and eventually lead to Uremia. Dialysis is another way to treat renal failure. It is just an alternative to ease the poisoning symptoms of Uremia patients temporarily, but cure Uremia. The cure rate for Uremia through dialysis is almost zero. If the patients depend on dialysis simply for long term, the following situations may appear: organs of the whole body are seriously impaired, complications occur and worsen, the living quality is decreased, the survival time is shortened, the original renal functions lose efficacy gradually and so on.

The combined Chinese and Western medicine treatment, which is with the Micro-Chinese medicine osmotherapy as the major method and the Western medicine as the assistant method, is a highly effective way to cure renal failure. There are three processes in Micro-Chinese medicine osmotherapy, first, promoting blood circulation and removing obstructions in venation; second, removing stasis and cleaning poisons; third, repairing and generating the new. In the first process, the renal blood perfusion as well as the micro-circulation of the whole body can be improved, then the fatigue of the whole body can get gradually eased. Promoting blood circulation and removing obstructions in venation is a very important process in Micro-Chinese medicine osmotherapy, which determine the later two processes. Then, in the second process, the poisonous substances in the body can be cleared up and in the third process, the impaired kidney can be repaired. After the treatment, the kidney disease will be cured eventually.

Does High Serum Creatinine Level Mean Decline in Kidney Function

When we talk of serum Creatinine, we mean Endogenous Serum Creatinine which is the metabolin of muscle. Through irreversible non-enzyme dehydration response, creatine can gradually become creatinine in muscle which is discharged into blood and then discharged out of body along urine. Serum Creatinine is micro-molecular substance which can be filtrated out by glomerulus with less reabsorbed by nephridial tubules. The creatinine formed in human body is almost discharged out of body along with urine and usually is not affected by urine volume. Clinically, serum creatinine is the key indicator for kidney function.

Usually speaking, the expected range of serum creatinine is 44-133umol/L. when serum creatinine in over 133umol/L, it means that the kidney is damaged and it can be Renal Insufficiency or renal Failure. When serum creatinine is above 133umol/L, it is the inflammatory damage stage; when over 186umol/L, it is the stage of renal damage; when over 451umol, it is the stage of renal failure (uremia at the end stage).

High serum creatinine usually means that kidneys are damaged. Though serum creatinine can reflect the situation of renal parenchyma, it is not a sensitive indicator, for serum creatinine will rise apparently only when the GFR declines to 1/3 of normal one. It means that patients don’t feel anything wrong when the renal damage is mild. If people have the symptoms like nausea, vomit, and dizziness, the renal damage is serious at the moment when serum creatinine begins to rise apparently. Therefore, people have to take a regular examination for kidneys. Early detection and timely treatment will prevent it from developing into Renal Failure or Uremia.

For more information about creatinine, please feel free to contact us at khkpcn@hotmail.com. We will reply to your questions as soon as possible.

What are Normal Creatinine Levels

The kidneys maintain the blood creatinine in a normal range. Creatinine has been found to be a fairly reliable indicator of kidney function. As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance by the kidneys. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys. It is for this reason that standard blood tests routinely check the amount of creatinine in the blood. A more precise measure of the kidney function can be estimated by calculating how much creatinine is cleared from the body by the kidneys and it is referred to creatinine clearance.

The typical reference ranges are 0.5 to 1.0 mg/dL (about 45-90 μmol/l) for women and 0.7 to 1.2 mg/dL (60-110 μmol/l) for men. In most of the countries, creatinine is typically reported in mg/dL, while in Canada and Europe μmol/litre may be used. 1 mg/dL of creatinine is 88.4 μmol/l1. The creatinine level is a very important reference for kidney disease. While a baseline serum creatinine of 2.0 mg/dL (150 μmol/l) may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 mg/dL (60 μmol/l) can indicate significant renal disease in a frail old woman.

It is very important to choose right treatment for abnormal creatinine level. So, if people find out their creatinine level is high, they should go to hospital first to find out what the cause is, then, receive a standard treatment. Traditional treatment for abnormal creatinine may be medicines or method which aims at the symptoms to treat. So, the disease is easy to relapse. We suggest you to adopt combined therapy of Chinese and Western medicine, namely Micro-Chinese Medicine Osmotherapy. 

If you have any question, welcome to send email to khkpcn@hotmail.com.

What Symptoms will Have If the Creatinine Level is High

Kidney is the important organ expelling of toxins. It maintains internal environment stable of body, through discharging metabolic wastes, adjusting body liquid, and excreting endocrine hormone. It plays important role on maintaining Human metabolism. High creatinine level is a very important manifestation of kidney disease deterioration. So, the patient appearing high creatinine should see the doctor immediately.

What symptoms will have, if the creatinine level is high? High creatinine level mainly has following symptoms:

1. Metabolism disorder of water

Diuresis, enuresis nocturna increase, thirst, nucous membrane dry, fatigue, etc, or general edema, high blood pressure, pulmonary edema, or heart failure, etc.

2. Metabolism disorder of sodium

High creatinine level also will appear hyponatremia or hypernatremia.

3. Metabolism disorder of potassium

High creatinine often is accompanied with hyperkalemia or hypokalemia.

4. Adidosis of Metabolism disorder

For the high creatinine patients, they may have long and deep breath, poor appetite, stomachache, nausea, vomit, fatigue, headache, move restlessly, even coma, etc.

5. Metabolic disorder of aluminium, magnesium, copper, zinc, selenium, etc.

6. Renal bone disease

Ostalgia, proximal muscle weakness.

7. respiratory system disease

8. cyclic system disease

9. alimentary system disease

10. blood system disease, like renal anemia, etc.

11. infection

12. Neuromuscular system disease and skin symptoms.

13. endoctrine function disorder

14 high creatinine patient also appear thyroid sysfunction, sexual dysfunction, grow slowly, etc.

15. metabolic disorder

Sugar dysbolism , fat dysbolism, protein, and amino acid dysbolism, metabolism retention, etc.

Through the above introduction, we know what symptoms will have for the high creatinine level patients. At present, some medicine or method, such as activated carbon and dialysis, etc. can only lower the creatinine level, but repair the bailar membrane and the damaged kidneys. In this case, the creatinine can only be decreased temporarily. Soon, the creatinine level will become high. So, we suggest the patient choose proper and effective treatment, such as Micro-Chinese medicine osmotherpay. How to treat High creatinine level by Micro-Chinese Medicine Osmotherpay? Welcome to send email to khkpcn@hotmail.com.