Relation between Creatinine and Glomerular Filtration Rate (GFR)

People with kidney disease are very sensitive to their serum creatinine levels but some of them are not very familiar with glomerular filtration rate (GFR). There is a close relationship between serum creatinine level and glomerular filtration rate.

Definition
Serum creatinine refers to end products of creatine in blood. Usually creatinine is excreted in urine and the level of serum creatinine remains fairly constant in healthy people. The normal level of serum creatinine is between 0.6 to 1.2mg/dL (50-110mmol/L) in general. The value is a little different from one hospital to another. Serum creatinine level is used to measure the kidney function since creatinine level may not increase without kidney dysfunction.

Glomerular filtration rate is estimated by a certain machine. Each of our kidneys contains 1 million to 2 million glomeruli. These glomeruli normally work to filtrate blood and to form urine through their physical structures and chemical reactions. Mostly, when your nephrologist talks to you the kidney function, he talks about the glomerular filtration rate. Glomerular filtration rate measures the blood volume that is filtrated in one minute by the glomeruli. Glomerular filtration rate is a very sensitive indicator that is used to describe the kidney filtration function. A lower than normal glomerular filtration rate usually means you have some degree of kidney dysfunction. Our lives are sustained by continual function of the kidneys. So you may have one or some discomforts with inadequate glomerular filtration rate.

Glomerular filtration rate describes the excretory function of kidney in eliminating serum creatinine. If your serum creatinine level is doubled than normal, your glomerular filtration rate is most probably halved. A three times high than normal serum creatinine level means that you only have 25% of kidney function left. These two indicators reflect each other every minute. The higher the glomerular filtration rate is, the lower the serum creatinine level will be and vice versa.

Form this introduction of serum creatinine and glomerular filtration rate; you may acquire some knowledge about serum creatinine and glomerular filtration rate. 

If you look for natural way to lower high creatinine, please refer to 'Diet Plan to Reduce High Creatinine Level' for more information.

If you have any specific questions, you can consult our on line service or email to khkpcn@hotmail.com.

How to Normalize Serum Creatinine Levels

To know the methods of normalizing serum creatinine levels, you should gain some knowledge about serum creatinine first. Measurement of serum creatinine levels is an essential method to detect renal function. In general, the normal range of serum creatinine for healthy adults is 0.6-1.2mg/dL (50-110mmol/L), but different hospital has different equipment to measure the serum creatinine according to the equipment and location.

To normalize increased serum creatinine, firstly you should know the diagnosis of your kidney problem. Although different kidney disease can all injure kidney tissues making kidney function decrease, the diagnosis and cause of certain kidney disease may help to determine the treatment priority. For example, if you are an IgA Nephropathy patient who has increased serum creatinine levels, you may already have Renal Failure. To normalize your higher than normal serum creatinine levels, the treatment should focus on cleaning away immune complex in mesangial area of kidney and repairing damaged kidney tissues.

To normalize high serum creatinine levels, corresponding treatment also plays an important role. If the treatment only emphasizes on alleviating symptoms of kidney disease instead of blocking the progression of the disease drastically, the disease will become worse sooner or later. At that time, even you use the best of the best treatment; your kidney function may not able to improve greatly. There are some treatments of kidney disease dedicate to treat kidney disease by using steroids and immunosuppressant only. Such medications do have undoubtedly effect to ease signs and symptoms of kidney disease and to make kidney disease patients feel better, but their side effects and disability of fixing damaged kidney tissue usually put kidney disease patients in another cruel predicament.

Another important factor of reducing high serum creatinine levels is daily care. Kidney disease patients with increased serum creatinine should watch out daily diet, life style and personal hygiene. You can consult a dietician to adjust your diet more detailed and integrated since different health condition and kidney disease need not the same diet. Throw away your bad life habits and establish good life habits, do regular exercise and have proper rest are all necessary.

Above are solutions of normalizing serum creatinine. If you are not clear above the things I mentioned the above, you can email to khkpcn@hotmail.com.

Does Renal Failure Affect Serum Creatinine Levels

Serum creatinine levels display a patient's kidney function. Normal value of serum creatinine level differs from one hospital protocol to another but it is around 0.6 to 1.2 mg/dL in general. People with different stages of Renal Failure usually have higher than normal serum creatinine levels.

Renal Failure is a general term indicating kidney dysfunction instead of a specific disease. It is a critical state caused by known or unknown diseases or factors. It results the kidney failing to remove waste and toxins from blood. Dysfunction of kidney can be represented by increasing serum creatinine levels.

Serum creatinine level measures the kidney excretory ability of cleansing toxins and waste from blood. Ordinarily, our kidneys work flawlessly to remove most toxins and waste from blood and then discharge them through urination. Therefore, the measurement of serum creatinine level is about 0.6 to 1.2mg/dL for the healthy people or mild Renal Failure patients.

Each kidney contains about more than 1 million to 2 millions nephrons. They are the basic functional unit of the kidney. They filtrate our blood and regulate fluid and electrolytes as well as acid-base balance of our bodies. Glomerulus, the small but significant part of a nephron is responsible for filtrating blood. If the glomeruli are damaged, toxins and waste will be left and gathered in bloodstream. Because each people have millions of nephrons only a few amount of glomerular damage may not be detected by serum creatinine level. That is to say, mild glomerular damage will not cause serum creatinine levels to go up. Whenever a Renal Failure patient's Serum Creatinine level increases, about at least 50% of glomerulus are destroyed. In a word, Renal Failure dose affect serum creatinine levels to increase without timely effective treatment.

Renal Failure patients with increased serum creatinine levels usually have one or some symptoms of Renal Failure, such as water retention, internal bleeding, and abnormal urination and so on. Further progression of Renal Failure may bring about more serious health problems. Patients with Renal Failure should treat increasing serum creatinine levels seriously because they imply more damage of glomeruli and worsening of kidney function. Please refer to 'How Immunotherapy Helps Reduce High Creatinine Levels' for more helpful information about treatment.

Foods to Lower High Serum Creatinine Level Naturally

Serum creatinine measures the effectiveness of an individual's kidney function. Normally, creatinine is regulated and excreted by the kidneys. Constant high serum creatinine usually indirectly indicates kidney dysfunction. Some studies have shown that food have a great impact on serum creatinine level therefore patients should watch their diets in case of increasing kidneys' load. There are some food suggestions for people with high serum creatinine.

1. Salt
If you have Hypertension or edema, you should restrict your salt intake in a very small amount. Too much salt intake elevates your blood pressure and worsens your edema.

2. Protein
Excessive protein intake exerts an extra burden to your kidneys. Your kidney function may become worsen further by extra intake of protein if you have any kidney disease. In addition, you should eat low amount quality protein (like lean meat, milk and egg white). Make sure your daily protein intake is not beyond 0.8g to 1.0g per Kilogram.

3. You can take fairly more food containing plenty of Vitamin A, Vitamin B2 and Vitamin C.

4. If you are a Uremic and your serum creatinine is very high, you should eat low-salt, low-potassium, low-fat, low protein and high vitamin diet strictly.

You should also cease smoking and drinking alcohol if your serum creatinine levels are higher than normal. What's more, preventive measures should also be taken to avoid air-borne communicable diseases and other infections. Serum creatinine levels may be reduced within normal if your kidney diseases are effectively treated. There are some symptomatic treatments only works for a short periods. Your serum creatinine levels and other abnormal laboratory findings may be decreased for some time but soon you will find those indicators go up again. Such phenomenon is caused because symptomatic treatment only alleviates your symptoms instead of really treats the disease itself.


You may consult our on line service to know if your current treatment is effective or not. You may also send your laboratory reports to khkpcn@hotmail.com to analyze your current illness condition and for more details.

What Does it Mean to Have a Serum CREATININE Level 1.3

We are often asked that what does it mean to have a serum creatinine level of 1.3, or a higher level, people are aware of something wrong happened on them, but some feel good and do not have any obvious symptoms, they are sacred of high serum creatinine level, and all of them want to know what does high creatinine level means and what can they do to lower the serum creatinine.

The kidneys are organs with strong reserve capacity, actually, we just use less than 50% of renal function on daily life, so if creatinine rises, it means that kidneys are damaged more than 50%, so the high creatinine level maybe not a coincidence.

So what happened exactly, the early kidney damage is different to discover, the healthy functional cells will occur phenotypic transformation. At this time, a series of cells which can cause renal toxicity and growth chemokines, and then combine and secrete various extracellular matrixes which are hard to be degraded. A large mass of extracellular matrixes will take place of healthy functional units, and then Glomerulosclerosis, interstitial fibrosis will occur, then serum creatinine can not be discharged timely and effectively, that is the reason why high serum creatinine level occurs.

Well, the renal function can be divided into four stages according to the level of serum creatinine:

I Serum creatinine level: 141.4-177 μmoI/L (1.6-2.0 mg/dl), at this stage, the patients will loss 20-25% nephron, but they may not feel obvious symptoms.

II Serum creatinine level: 185.9-442.6mmol/L (2.1-5.0 mg/dl), at this stage, the patients will loss 50-70% nephron, and some symptoms such as Nocturia, weakness, edema anorexia, nausea and mild anemia may occur.

III Serum creatinine level: 442.-708.2 mmol/L (5.0-8.0 mg/dl), at this stage, the patients will loss 70-90% nephron, and patients also will suffer with severe anemia, edema, nausea, vomiting, metabolic acidosis, hypocalcemia and hyperphosphataemia.

IV Serum creatinine level: >708.2 mmol/L (>8.0 mg/dl), at this stage, except some serious symptoms, the patients will need dialysis to sustain their life.


Now we know what does it mean to have a high serum creatinine level, the timely treatment for kidney patients are necessary. Please refer to 'How to Reduce the High Creatinine Effectively' for more information.

Is There Any Remedy to Reduce High Creatinine Levels Naturally

Is there any remedy to reduce high creatinine levels naturally? Most kidney patients are concerned about this question. Indeed, creatinine level is an important index to judge their kidney problem, both patients and doctors can know how the illness condition of patients from this indicator is. However, the increasing of creatinine level is just a symptom of kidney disease. So the point is how creatinine level increases instead of how to reduce the creatinine level.

The following are some possible reasons that could cause high creatinine:

I For the patients with renal insufficiency, if they get a cold, Pneumonia, intestinal infection, urinary tract infection or some other kinds of infections, a sudden increase of creatinine level is possible;

II if kidney disease patients take some medicines which are harmful to kidneys, the creatinine may increase as well;

III Overfatigue, sleep insufficiency or some details in life could also cause transitional high creatinine;

IV Patients with high blood pressure, if they can not control their hypertension well, or they suffer with a large amount of proteinuria (the volume of protein in urine is over 1 or even 1.5 g per 24 hours), as this condition, the creatinine level is easy to rise.


The above-mentioned several points can be the reason of creatinine level increase. If patients found their creatinine rises, it is really necessary for them to go to the local hospital (kidney disease specialized hospital is best), to test their blood, urine as well as renal function, to have a better understand of both their body and kidney situation. A early precautions and treatment are helpful to the favorable prognosis. And patients can not hold the idea that “everything will be OK” when they found kidney problem, this is a disease which can not be cured totally, and if we want to have a easy life, we must pay special attention on it!

What Does it Mean When Your Creatinine Level Increase

High Creatinine level indicates serious kidney function decline. Kidney has powerful compensatory ability, which means that slight kidney function decline will not lead to creatinine level increase. Once there is creatinine level increase, overall kidney function decline has already progressed into the third or fourth stage (overall kidney function has already decreased by 50%).

Creatinine is the product of Muscle metabolic activity, so it is related closely with people’s physical activities. Even though daily creatinine producing differs from person to person, kidney can excrete out approximately all newly produced creatinine within body and keep its level within a certain range (commonly 0.8-1.3mg/dl). Due to kidney’s powerful compensatory ability, slight damage will cause no serious creatinine level increase, but once there is serious creatinine level, kidney function decline has already become very serious.

Creatinine level is affected by many matters like physical activities, infection in urinary system, even common infections and so on, but continuous high creatinine level most probably indicates to kidney function decline.

Cases can be like this; abnormal creatinine level is detected, but stays in a relatively low range like 2.0-3.0mg/dl, and this condition can last for years, with no obvious symptoms or discomforts. Then, what should they do?

Kidney disease is actually a progress of kidney function decline. What matters is the prognosis of long term illness condition. Healthy lifestyle and restricted Diet helps with slowing down this progression, but not blocking it. So, it may take ten years to progress into kidney failure, or it may take fifteen years, but the final result is the same. And, clinical practices have already proven that the recovery of late stage kidney function decline is even more difficult. In Traditional Chinese Medical concept, we cherish the philosophy of treating disease before its causing serious trouble to human body. So, my suggestion on patients with relatively not very high creatinine levels is prompt proper treatment adoption.
From the above context, you can tell that creatinine level increase indicates kidney function decline. Then, I think you may already get the answer on how to reduce creatinine level---blocking the progression and restore kidney function.

In China, Micro-Chinese Medicine Osmotherapy and Immunotherapy are adopted in blocking further kidney function decline and restoring overall kidney function. If you or somebody you loved is now facing with increased creatinine level, do not be despaired, the concept of kidney disease has no treatment has already become a concept out of data.

This article mainly concerns high creatinine, you can send an e-mail to khkpcn@hotmail.com for expert's analysis on your specific condition.