The Bad Impact of Proteinuria on Kidneys

Proteinuria is not only a sign of glomerular damage but also a factor which leads to the fibrosis of nephridial tubules and mesenchyma. but how does the damage happen when patients have proteinuria?
Proteinuria components include moderate-molecular protein, macro-molecular protein, micro-molecular protein and growth factor. As moderate-molecular protein dominates in proteinuria, I'd like to introduce how moderate-molecular protein leads to kidney damage.

Moderate-molecular protein include albumin and transferrin. Albumin which is the main cause of tubulointerstitial fibrosis accounts for 50%-60% in glomerular proteinuria.

Albumin can stimulate the functional renal cells to produce chemotactic factor, which lead to the inflammatory reaction. Besides, albumin can combine with many substances in humane body like fatty acid to form toxic metabolin in kidney, which can lead to damage to renal tissues and renal cells. All these conditions can cause kidney disease.

Transferrin can combine with iron taken in by human body and when the combination goes through kidneys, it releases the iron, which can cause damage to renal mesenchyma. What’s more, transferrin can cause the hyperplasia of mesangial cells and then produce more extracellular matrixes. Therefore, as the transferrin in urine increases, it may lead to renal fibrosis and then decline in renal function.

But how to reduce protein in blood? Clinical practice has proven that the combination of Micro-Chinese Medicine Osmotherapy and Immunotherapy is effective and convenient. As long as patients persistent in long-term and standard treatment, a good curative effect will be achieved.

For more information, please feel free to contact at khkpcn@hotmail.com. We are ready to help you to be in a good health.

Common Causes of Proteinuria (Protein in Urine)

Proteinuria refers to that there is an abnormal amount of protein in urine. Albumin is the main protein in the blood. As blood passes through healthy kidneys, they filter out the waste products and leave in the things body needs, like albumin and other proteins. However, proteins from the blood can leak into the urine when there is something wrong with kidneys i.e. the glomerulus is damaged for no matter what reasons.

There are frequently no symptoms associated with proteinuria, especially in mild cases. Large amounts of protein may cause the urine to appear foamy. Significant loss of protein from the blood can affect the body’s ability to regulate fluids, which can lead to swelling in the hands, feet, abdomen, and face. When symptoms are present, they are usually associated with the condition or disease causing proteinuria.

Higher than normal blood pressure is a common cause of proteinuria. The kidneys are damaged by the elevated blood pressure, which eventually results in the passage of protein into the urine.

Other causes of proteinuria include diabetes, kidney infection, or other types of kidney inflammation. If left untreated, conditions that causes proteinuria can lead to a severe condition, end-stage renal (kidney) disease.

Proteinuria is a sign of kidney disease, which can result from diabetes, high blood pressure, and diseases that cause inflammation in the kidneys. For this reason, testing for albumin in the urine is part of a routine medical assessment for everyone. If kidney disease develops, it can develop into end-stage renal disease, when the kidneys fail completely. A person with ESRD must receive a kidney transplant or dialysis.

If you have the symptom proteinuria, you have to diagnosis which stage of chronic disease you are in and then receive an early and proper treatment to prevent it from developing into irreversible situation.

Reduce Urine Protein in CKD with Micro-Chinese Medicine

Many chronic kidney diseases, such as chronic nephritis, nephrotic syndrome, and chronic renal tubule interstitial disease, etc, will show urine protein in different levels clinically. At this time, the appearance of urine protein indicates the glomerular filtration barrier or epithelial cells of renal tubule may be injured pathologically in different forms and levels. Thus, various proteins which should be not filtered out or reabsorbed into blood are discharged from body, forming urine protein.

According to the current most advanced diagnosis and treatment therapy of kidney disease, “Renal fibrosis theory”, although pathological changes causing urine protein are different in types, all they belong to the progressive process of renal fibrosis. Extracellular matrix deposits abnormally more and more, and normal renal inherent cells become less and less until disappearance completely, the disease develops into Uremia. Renal fibrosis is the root cause of renal urine protein. So, treatment of chronic kidney disease and elimination of urine protein must start with blocking renal fibrosis. Otherwise, urine protein can not be eliminated completely, causing the disease to relapse and protract easily.
Chinese nephrologists adopt Micro-Chinese Medicine multi-targeted therapy to block renal fibrosis and repair damaged renal inherent cells. After the active substances of Micro-Chinese Medicine enters into body, they will play four effects, including dilating blood vessels, anti-inflammatory, anti-coagulation, and degradation, to repair renal inherent cells and alleviate urine protein.

1. Dilate blood vessels to alleviate urine protein
Various inherent cells, basilar membrane, and epithelia cells of glomerular tubules, which maintain glomerular filtration barrier of chronic kidney disease patient normal, are damaged by various kinds of pathogenic factors, such as immune complex, pathogenic bacteria infection, etc, causing ischemia and anoxia on damaged part. Micro-Chinese Medicine dilates different levels of arteries of patients’ kidneys first, increase renal perfusion, improve the condition of ischemia and anoxia on damaged parts, and increase the supplement of nutrient substances for self-repair of the damaged parts.
CKD patients with urine protein are mostly accompanied with symptoms of digestive tract, inappetence. Micro-Chinese Medicine can improve the patients’ appetite through dilating blood vessels in digestive tract and improving digestive blood circulation, so as to enhance the patient’s physique and create condition for the disease recovery. It is especially important for patients who are Protein malnutrition resulted from large amount of urine protein.
Micro-Chinese Medicine Osmotherapy can dilate arteries over body and relieve the symptom of general malaise caused by kidney disease.
While receiving treatments, the patients can experience the above two effects themselves in short term.

2. Anti-inflammation to alleviate urine protein
When glomerular filtration barrier and kidney tubules epithelial cells are damaged, the injured parts will attract inflammatory cells in blood to be soaked by them, releasing Nephrotoxicity inflammatory medium, promoting the cells to translate into Myofibroblast, and speeding up the progressive course of renal fibrosis. Therefore, renal fibrosis can not be blocked, if inflammation is not removed.
Micro-Chinese Medicine can inhibit the activity of inflammatory cells and Nephrotoxicity inflammatory medium, prevent the phenotypic transformation of renal inherent cells, and block renal fibrosis from the angle of anti-inflammation.

3. anti-coangulation
For the CKD patient, when their glomerular filtration barrier is damaged, the coagulation activation will be activated, attracting platelet in the blood circulation to gather in the damaged area, forming microthrombus and aggravating state of anoxia and ischemia. Micro-Chinese Medicine can inhibit the formation of microthrombus and improve the blood circulation of the damaged area in in several different ways. The effects of both dilating blood vessels and anti-coagulation of Micro-Chinese Medicine can correct anoxia and ischemia.

4. Degradation
After renal fibrosis activating, the balance between generation and degradation of extracellular matrix will be broken. Abnormal deposition of extracellular matrix will become more and more and renal inherent cells will become less and less, and each kind of renal physiological functions will lose gradually. Micro-Chinese Medicine can adjust the balance between generation and degradation of extracellular matrix, degrade and eliminate abnormal deposition of extracellular matrix, and block its incessant invasion to glomerular and renal tubule inherent cells, so as that the glomerular filtration function, and reabsorpation of renal tubule will obtain protection and restoration, as well as the urine protein symptoms will be relieved. Micro-Chinese Medicine can also promote the elimination of immune complex, metabolin, and Necrotic tissue, etc. At this time, the foam in urine will decrease, urine protein parameter of text will be improved, urine odor become strong, deposition in urine will increase as well, etc. All the above indicate that the degradation function of micro-Chinese Medicine does work.
As long as the renal fibrosis can be blocked effectively, and damaged renal inherent cell can be repaired in place, then, the patient’s physique is improved and the urine protein of Chronic Kidney disease will disappear completely. If you have any question about chronic kidney disease, please send email to khkpcn@hotmail.com. we will try our best to help you.

Is milk good for patients with Renal Proteinuria

Protein plays an important role in human health. In order to assure nutrition and the needs of organ, patients must take proper high quality protein, such as milk, eggs, lean meat etc. It is essential to drink 250ml milk every day. However, as for kidney disease patients, they should limit the intake of bean curd, bean products and other vegetable protein. Although food of this kind contains high protein, thick qualitative protein will burden the kidney and deteriorate renal function.

The advantage of drinking milk for patients with Renal Proteinuria

Ⅰ. The content of high quality protein in milk occupies 80% of total protein content. The protein not only contains full range of essential amino-acid with sufficient quantity, but its structure is close to the human body, which is benefit for absorption and utilization of nutrition.

Ⅱ. Besides the protein, other nutrition constituent in milk is also good for patients' health. Patients with Chronic Renal Insufficiency usually has ratio imbalance between calcium and phosphorus, but the proportion is appropriate in milk, which can make a great effect to correct the imbalance.

Ⅲ. Patients with kidney disease usually take less protein, so calorie should not be limited excessively. The fat content in milk is about 2%—3.2% with abundant nutrition, which is easy to be assimilated. It is suitable for the patients and it can also moist skin and lightens the symptoms caused by illness, such as dry skin, yellowed hair etc.

Ⅳ. Carbohydrate in milk is lactose, which can adjust gastric acid, promote gastrointestinal motility and secretion of glandula digestive. It can also promote the absorption of calcium. The lactose in milk is not much, only about 10 gram. Therefore, patients with Diabetic Nephropathy can also drink milk every day without sugar; it won't cause the fluctuation of blood sugar.

How to Define Oliguria and Anuria

Clinically Oliguria is defined as less than 400ml urine within 24 hours or less than 17 ml urine per hour; while less than 100ml urine is referred to as Anuria. Patients with Oliguria and Anuria often suffer increasing creatinine and urea nitrogen, electrolyte balance out of order, and metabolic acidosis, etc. Clinically there are three common reasons which can lead to Oliguria or Anuria:

The first one is prerenal factor. The decrease of effective circulating blood in the whole body leads the renal blood flow to drop and it can also lead glomerular filtration pressure and filtration rate to descend, all of which cause urine volume to decline. This phenomenon is often seen in dehydration, heart failure, shock, hypotension, thrombosis of the renal artery, etc.

The second one is renal factors. Renal parenchymal damage leads to Oliguria and Anuria, which are found in acute nephritis, acute progressive nephritis, acute interstitial nephritis, acute tubular necrosis, and renal failure which is cause by various chronic glomerulonephritis.

The last one is post-renal factor. It is mainly caused by urinary tract obstruction, and is often due to renal pelvis stone, ureteral calculus, lump obstruction in ureter, Ureteral inflammation, edema, stenosis, or obstruction caused by oppression adhesion from outside kidneys.

The Pathogeny of Urine Protein

Proteinuria may appear when Glomerular and tubular have pathological changes, such as periods nephritis, nephropathy as well as Hypertension and Renal Arteriosclerosis. Various bacterial infections can also cause Proteinuria, such as pyelonephritis, nephrophthisis, ichorrhemia etc. Proteinuria can also caused by noninfectious diseases, such as kidney stone, Polycystic Kidney, Renal Amyloidosis as well as shock, severe muscle damage, fever, jaundice, hyperthyroidism, hemolytic anemia, leukemia etc.

Physiological Proteinuria can commonly be seen after high protein diet intake, psychokinesia, strenuous exercises, chilling for a long time, pregnancy etc will cause temporal Proteinuria, with which the Urine Protein Qualitative is less than +.

In general, continuous Proteinuria often represents kidney disease. The amount of Urine Protein reflects the degree of lesion, and people can observe according to its efficacy clinically. However, in particular, to the end stage of glomerular abnormalities, because large amount of damaged nephrons, the leaching of protein reduces, which is not mean to lighten kidney disease.

Proteinuria caused by the reasons besides kidney disease

Most of Proteinuria caused by the reasons besides kidney disease is benign; Proteinuria may vanish after other diseases are cured.

Hot Proteinuria

When patients with the fever caused by cold reaching up above 38℃, Proteinuria will occur.

Stand Proteinuria.

The occurrence of Proteinuria caused by forward flexion of spine oppressing the vessels of kidney of young people, which may disappear around 30 years old of the people without treatment.

Cyanotic kidney

People with renal venous stasis, such as heart failure will appear Urine Protein. However, it will vanish after disappearing of blood stasis.

Proteinuria caused by kidney diseases

It is obvious that people with kidney disease always appear urine protein after urine routine.

Nephritis

It can be divided into Acute Nephritis and Chronic Nephritis.

Nephrotic Syndrome

The protein from urine will decrease the density of protein. In addition, it is also caused by other conditions, such as Diabetic Nephropathy, Amyloidosis, collagen disease etc.

Nephrosclerosis

Nephrosclerosis caused by Essential Hypertension has less urine volume, which is mostly less than 300mg.

In addition, Multiple Myeloma, Systemic Lupus Erythematosus, Chronic Rheumatic Arthritis, Gout, Edema as well as Mercurialism and lead poisoning will cause Urine Protein.

Is Renal Transplantation the only Option for Children with End Stage Renal Failure

Renal transplantation is considered to be the best treatment for children with End Stage Kidney Disease. It can reduce their death risk significantly to sustain their life. However, the parents need to take the cons and pros of the transplantation into consideration before taking the therapy.

Renal graft dysfunction
Renal graft dysfunction is the primary problem for children. The causes of renal allograft dysfunction vary with the time after transplantation. In some cases, the new kidney may fail in less than one week post-surgery. It mainly results from the following factors:
Postischemia acute kidney injury, vascular thrombosis of the renal artery or vein, recurrent or de novo renal disease, infection, urinary obstruction, etc.

Complications
After renal transplantation, the children have to rely on immunosuppressive drugs to suppress the rejection reaction. Long-term use of these drugs can cause a myriad of complications.

Infection and cancer
After renal transplantation, children have to rely long-term use of immunosuppressive drugs to suppress the immune system. However, the medication therapy places the recipient under increased risk of cancer and infection.

Osteoporosis
Immunosuppressive drugs can accelerate the protein decomposition and slow down its synthesis, which is a cause for osteoporosis. Also, it can disorder the metabolism of calcium and phosphorus as well as restrain the absorption of calcium. Osteoporosis can increase the fragility and cause retardation.

High risk of Diabetes and cardiovascular diseases
Immunosuppressive drugs can disorder the sugar metabolism and place the children at risk of Diabetes. The parents should monitor their child's sugar level regularly. Additionally, receiving a renal transplantation increases the children's risk of high blood pressure and high cholesterol. Both of them are important factors in causing cardiovascular diseases like stork and heart attack.

Since there are so many potential risks and complications of renal transplantation. Is there an alternative therapy for the children?
Immunotherapy brings extraordinary promising for patients with End Stage Renal Failure. It is designed to restore the impaired kidneys.